DICER1: mutations, microRNAs and mechanisms

@article{Foulkes2014DICER1MM,
  title={DICER1: mutations, microRNAs and mechanisms},
  author={William D Foulkes and John R. Priest and Thomas F. Duchaine},
  journal={Nature Reviews Cancer},
  year={2014},
  volume={14},
  pages={662-672}
}
Dicer is central to microRNA-mediated silencing and several other RNA interference phenomena that are profoundly embedded in cancer gene networks. Most recently, both germline and somatic mutations in DICER1 have been identified in diverse types of cancer. Although some of the mutations clearly reduce the dosage of this key enzyme, others dictate surprisingly specific changes in select classes of small RNAs. This Review reflects on the molecular properties of the Dicer enzymes in small RNA… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 30 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 89 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 129 references

Similar Papers

Loading similar papers…