DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification.

@article{DazGarca2013DICER1DA,
  title={DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification.},
  author={Carmen Vanesa D{\'i}az-Garc{\'i}a and Alba Agudo-L{\'o}pez and Carlos Vilaplana P{\'e}rez and Jose Antonio L{\'o}pez-Mart{\'i}n and Jos{\'e} Luis Rodr{\'i}guez-Peralto and Javier de Castro and Ana Cortijo and Miriam Mart{\'i}nez-Villanueva and Lara Lloret Iglesias and Roc{\'i}o Garc{\'i}a-Carbonero and Juan Angel Fresno Vara and Angelo G{\'a}mez-Pozo and Jos{\'e} Palacios and Hern{\'a}n Cort{\'e}s-Fun{\'e}s and Luis Paz-Ares and Mar{\'i}a Teresa Agull{\'o}-Ortu{\~n}o},
  journal={Carcinogenesis},
  year={2013},
  volume={34 5},
  pages={1031-8}
}
The clinical and functional significance of RNA-interference machinery in lung cancer is poorly understood. Besides, microRNAs (miRNA) have the potential to serve both as biomarkers and therapeutic agents, by personalizing diagnosis and therapy. In this study, we investigated whether the expression levels of DICER1 and DROSHA, components of the RNA-interference machinery, can predict survival, and whether the miRNA expression profiles can differentiate histologic subtypes in non-small cell lung… CONTINUE READING