DIARRHOEA IN VIPOMA PATIENTS ASSOCIATED WITH COSECRETION OF A SECOND ACTIVE PEPTIDE (PEPTIDE HISTIDINE ISOLEUCINE) EXPLAINED BY SINGLE CODING GENE

@article{Bloom1983DIARRHOEAIV,
  title={DIARRHOEA IN VIPOMA PATIENTS ASSOCIATED WITH COSECRETION OF A SECOND ACTIVE PEPTIDE (PEPTIDE HISTIDINE ISOLEUCINE) EXPLAINED BY SINGLE CODING GENE},
  author={Stephen R. Bloom and Nicholas D Christofides and John Delamarter and Gary N. Buell and E. Kawashima and Julia M P Polak},
  journal={The Lancet},
  year={1983},
  volume={322},
  pages={1163-1165}
}
Peptide histidine isoleucine (PHI), first isolated from pig intestine, is distributed identically to vasoactive intestinal peptide (VIP) in all mammals. 42 patients with high plasma VIP secondary to VIPoma also had very high plasma PHI-like immunoreactivity, in a constant ratio to VIP. None of 125 patients with other endocrine tumours had high levels of either peptide. VIPoma tissue from 20 patients also contained PHI shown by immunocytochemistry to be produced by the same cell as VIP… CONTINUE READING

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