DIALIGN-T: An improved algorithm for segment-based multiple sequence alignment

  title={DIALIGN-T: An improved algorithm for segment-based multiple sequence alignment},
  author={Amarendran R. Subramanian and Jan Weyer-Menkhoff and Michael Kaufmann and Burkhard Morgenstern},
  journal={BMC Bioinformatics},
  pages={66 - 66}
We present a complete re-implementation of the segment-based approach to multiple protein alignment that contains a number of improvements compared to the previous version 2.2 of DIALIGN. This previous version is superior to Needleman-Wunsch-based multi-alignment programs on locally related sequence sets. However, it is often outperformed by these methods on data sets with global but weak similarity at the primary-sequence level. In the present paper, we discuss strengths and weaknesses of… CONTINUE READING
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