Corpus ID: 38790335

DIAGNOSTIC AND SURGICAL TECHNIQUES

@inproceedings{Teus2009DIAGNOSTICAS,
  title={DIAGNOSTIC AND SURGICAL TECHNIQUES},
  author={M. Teus and L. Benito-Llopis and J. Ali{\'o}},
  year={2009}
}
2009 by All rights Abstract. Mitomycin C has played a deciding role in the current revival of excimer laser surface ablation techniques. We review the literature regarding mechanism of action of mitomycin C, histological effects on the cornea, and indications, dose, exposure time, and toxicity of mitomycin C in corneal refractive surgery. Mitomycin C is an alkylating agent with cytotoxic and antiproliferative effects that reduces the myofibroblast repopulation after laser surface ablation and… Expand
1 Citations

Figures and Tables from this paper

Modeling and Simulation in the Light of Decision-Making, Emergent Structures and a World of Non-Linearity
  • 2014

References

SHOWING 1-10 OF 170 REFERENCES
Evaluation of the prophylactic use of mitomycin‐C to inhibit haze formation after photorefractive keratectomy
TLDR
The prophylactic use of a diluted mitomycin‐C 0.02% solution applied intraoperatively in a single dose after PRK produced lower haze rates, better UCVA and BCVA results, and more accurate refractive outcomes than those achieved in the control group. Expand
Effect of prophylactic and therapeutic mitomycin C on corneal apoptosis, cellular proliferation, haze, and long-term keratocyte density in rabbits.
TLDR
Treatment with 0.002% mitomycin C for 12 seconds to 1 minute appears to be just as effective as higher concentrations for longer duration in the rabbit model, however, a persistent decrease in keratocyte density in the anterior stroma could be a warning sign for future complications and treatment should be reserved for patients with significant risk of developing haze after PRK. Expand
Scraping and mitomycin C to treat haze and regression after photorefractive keratectomy for myopia.
TLDR
Single application of diluted mitomycin C 0.02% solution following scraping of the corneal surface was effective and safe in treating haze and regression after PRK in patients who had previously undergone PRK for myopia. Expand
Permanent corneal edema resulting from the treatment of PTK corneal haze with mitomycin: a case report.
TLDR
The author believes that the use of mitomycin C as a 1-time application at the end of surgery is a safe and valuable adjunct to recover vision when no other is known, however, continued topical application to the central cornea, in the face of an epithelial defect or an epithelium with inadequate barrier function, increases the risk of endothelial damage. Expand
Topical mitomycin-C for subepithelial fibrosis after refractive corneal surgery.
TLDR
Topical application of MMC (0.02%) may be a successful method of preventing recurrence of subepithelial fibrosis after debridement and/or keratectomy in patients who have undergone refractive corneal surgery. Expand
Effect of mitomycin‐C on the corneal endothelium during excimer laser surface ablation
TLDR
A single intraoperative application of MMC 0.02% for 30 seconds after laser surface ablation did not seem to cause a substantial change in corneal endothelial cell density. Expand
Evolution, techniques, clinical outcomes, and pathophysiology of LASEK: review of the literature.
TLDR
The long-term stable results in the absence of serious complications, such as infections, recurrent erosions, scars, or late-onset corneal haze formation in patients re-examined up to 5 years after LASEK are provided. Expand
Prophylactic mitomycin C to inhibit corneal haze after photorefractive keratectomy for residual myopia following radial keratotomy.
TLDR
A single intraoperative application of MMC 0.02% for 2 minutes appears to be effective in preventing subepithelial haze after PRK for residual myopia in patients with undercorrection or regression following RK. Expand
Effect of mitomycin C on the corneal endothelium when used for corneal subepithelial haze prophylaxis following photorefractive keratectomy.
TLDR
Administration of MMC for haze prophylaxis following PRK did not have a significant effect on quantitative endothelial cell density or qualitative morphometric parameters in this study. Expand
Mitomycin C reduces scar formation after excimer laser (193 nm) photorefractive keratectomy in rabbits
TLDR
While the grade of haze showed no relevant differences between the two groups, scar tissue was found histologically in the mitomycin group in only 1 of 8 corneas compared with 5 of 8 in the BSS group. Expand
...
1
2
3
4
5
...