DHX9/RHA Binding to the PBS-Segment of the Genomic RNA during HIV-1 Assembly Bolsters Virion Infectivity.

@article{Boera2016DHX9RHABT,
  title={DHX9/RHA Binding to the PBS-Segment of the Genomic RNA during HIV-1 Assembly Bolsters Virion Infectivity.},
  author={I. Boeraş and Z. Song and A. Moran and J. Franklin and W. C. Brown and Marc C. Johnson and K. Boris-Lawrie and X. Heng},
  journal={Journal of molecular biology},
  year={2016},
  volume={428 11},
  pages={
          2418-2429
        }
}
Cellular RNA-binding proteins incorporated into virions during human immunodeficiency virus type 1 (HIV-1) assembly promote the replication efficiency of progeny virions. Despite its critical role in bolstering virion infectivity, the molecular basis for the incorporation of DHX9/RNA helicase A (RHA) to virions remains unclear. Here, cell-based experiments demonstrate that the truncation of segments of the HIV-1 5'-untranslated region (5'-UTR) distinct from the core encapsidation sequence… Expand
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