DHTKD1 is essential for mitochondrial biogenesis and function maintenance.

  title={DHTKD1 is essential for mitochondrial biogenesis and function maintenance.},
  author={Wangyang Xu and Houbao Zhu and Mingmin Gu and Qingqiong Luo and Jieying Ding and Yuting Yao and Fuxiang Chen and Zhugang Wang},
  journal={FEBS letters},
  volume={587 21},
Maintaining the functional integrity of mitochondria is crucial for cell function, signal transduction and overall cell activities. Mitochondrial dysfunctions may alter energy metabolism and in many cases are associated with neurological diseases. Recent studies have reported that mutations in dehydrogenase E1 and transketolase domain-containing 1 (DHTKD1), a mitochondrial protein encoding gene, could cause neurological abnormalities. However, the function of DHTKD1 in mitochondria remains… CONTINUE READING