DHT selectively reverses Smad3-mediated/TGF-beta-induced responses through transcriptional down-regulation of Smad3 in prostate epithelial cells.

@article{Song2010DHTSR,
  title={DHT selectively reverses Smad3-mediated/TGF-beta-induced responses through transcriptional down-regulation of Smad3 in prostate epithelial cells.},
  author={Kyung Suk Song and Hui Wang and Tracy L. Krebs and Bingcheng Wang and Thomas Kelley and David Danielpour},
  journal={Molecular endocrinology},
  year={2010},
  volume={24 10},
  pages={2019-29}
}
Androgens suppress TGF-β responses in the prostate through mechanisms that are not fully explored. We have recently reported that 5α-dihydrotestosterone (DHT) suppresses the ability of TGF-β to inhibit proliferation and induce apoptosis of prostatic epithelial cells and provided evidence that such suppression was fueled by transcriptional down-regulation of TGF-β receptor II (ΤβRII). We now show that androgen receptor (AR) activated by DHT suppresses the TGF-β-induced phosphorylation of Sma… CONTINUE READING

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