DHPLC analysis of potassium ion channel genes in congenital long QT syndrome.

@article{Jongbloed2002DHPLCAO,
  title={DHPLC analysis of potassium ion channel genes in congenital long QT syndrome.},
  author={Roselie J. E. Jongbloed and Carlo L Marcelis and Crool Velter and Pieter A. F. M. Doevendans and Joep P. M. Geraedts and Hubert J. M. Smeets},
  journal={Human mutation},
  year={2002},
  volume={20 5},
  pages={382-91}
}
Congenital long QT syndrome (LQTS) is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). As a result of these arrhythmias, patients suffer from recurrent syncopes, seizures, or sudden death as the most dramatic event. Mutations in five genes, encoding cardiac ion channels, have been identified in LQTS. Two potassium-channel genes, KCNQ1 (LQT1) and KCNH2 (LQT2 or HERG), are frequently involved in LQTS. Potassium-channel… CONTINUE READING
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