DHODH modulates transcriptional elongation in the neural crest and melanoma

@article{White2011DHODHMT,
  title={DHODH modulates transcriptional elongation in the neural crest and melanoma},
  author={Richard M White and Jennifer Nell Cech and Sutheera Ratanasirintrawoot and Charles Y. Lin and Peter B. Rahl and Christopher J. Burke and Erin Langdon and Matthew L. Tomlinson and Jack T. Mosher and Charles K Kaufman and Frank Jun Chen and Hannah K Long and Martin Kramer and Sumon M. Datta and Donna S Neuberg and Scott R. Granter and Richard A. Young and Sean Morrison and Grant N Wheeler and Leonard I. Zon},
  journal={Nature},
  year={2011},
  volume={471},
  pages={518-522}
}
Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the most commonly mutated gene in human melanoma. We have used zebrafish embryos to identify the initiating transcriptional events that occur on activation of human BRAF(V600E) (which encodes an amino acid substitution mutant of BRAF) in the neural… CONTINUE READING
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