DHEA inhibits cell growth and induces apoptosis in BV-2 cells and the effects are inversely associated with glucose concentration in the medium.

@article{Yang2000DHEAIC,
  title={DHEA inhibits cell growth and induces apoptosis in BV-2 cells and the effects are inversely associated with glucose concentration in the medium.},
  author={Nae-Cherng Yang and Kee Ching G Jeng and W M Ho and S J Chou and M. L. Hu},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2000},
  volume={75 2-3},
  pages={159-66}
}
Dehydroepiandrosterone (DHEA), a major steroid secreted by the adrenal gland which decreases with age after adolescence, is available as a nutritional supplement. DHEA is known to have antiproliferative effects but the mechanism is unclear. In this study using BV-2 cells, a murine microglial cell line, we investigated the effect of DHEA on cell viability and the interaction between DHEA and glucose concentrations in the medium. We showed that DHEA inhibited cell viability and G6PD activity in a… CONTINUE READING

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