DHEA-induced modulation of renal gluconeogenesis, insulin sensitivity and plasma lipid profile in the control- and dexamethasone-treated rabbits. Metabolic studies.

@article{Kiersztan2016DHEAinducedMO,
  title={DHEA-induced modulation of renal gluconeogenesis, insulin sensitivity and plasma lipid profile in the control- and dexamethasone-treated rabbits. Metabolic studies.},
  author={Anna Kiersztan and Andrzej Nagalski and Paweł Nalepa and Aleksandra Tempes and Nina Trojan and Michał Usarek and Adam K. Jagielski},
  journal={Biochimie},
  year={2016},
  volume={121},
  pages={
          87-101
        }
}
In view of antidiabetic and antiglucocorticoid effects of dehydroepiandrosterone (DHEA) both in vitro and in vivo studies were undertaken: (i) to elucidate the mechanism of action of both dexamethasone phosphate (dexP) and DHEA on glucose synthesis in primary cultured rabbit kidney-cortex tubules and (ii) to investigate the influence of DHEA on glucose synthesis, insulin sensitivity and plasma lipid profile in the control- and dexP-treated rabbits. Data show, that in cultured kidney-cortex… CONTINUE READING