DHEA and the Intracrine Formation of Androgens and Estrogens in Peripheral Target Tissues: Its Role during Aging

@article{Labrie1998DHEAAT,
  title={DHEA and the Intracrine Formation of Androgens and Estrogens in Peripheral Target Tissues: Its Role during Aging},
  author={F. Labrie and A. B{\'e}langer and V. Luu‐The and C. Labrie and B. Candas},
  journal={Steroids},
  year={1998},
  volume={63},
  pages={322-328}
}
  • F. Labrie, A. Bélanger, +2 authors B. Candas
  • Published 1998
  • Biology, Medicine
  • Steroids
  • Human and some other primates are unique since their adrenals secrete large amounts of dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S), which are converted into androstenedione (4-dione) and then into potent androgens and estrogens in peripheral tissues, therefore providing autonomous intracrine control to target tissues that can adjust the formation and metabolism of active sex steroids according to local requirements. Knowledge in this area has recently made rapid progress with the… CONTINUE READING
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