DHE repression of ATP-mediated sensitization of trigeminal ganglion neurons.

@article{Masterson2010DHERO,
  title={DHE repression of ATP-mediated sensitization of trigeminal ganglion neurons.},
  author={Caleb G. Masterson and Paul L. Durham},
  journal={Headache},
  year={2010},
  volume={50 9},
  pages={
          1424-39
        }
}
  • Caleb G. Masterson, Paul L. Durham
  • Published 2010
  • Medicine
  • Headache
  • OBJECTIVE To investigate the mechanism by which adenosine triphosphate (ATP) causes sensitization of trigeminal neurons and how dihydroergotamine (DHE) represses this modulatory effect. BACKGROUND Dihydroergotamine is an effective treatment of migraine. The cellular mechanisms of action of DHE in treating migraine attacks remain unclear. METHODS In this study, neonatal rat trigeminal ganglia cultures were used to investigate effects of ATP, alpha, beta-methyl ATP (α,β-meATP), and DHE on… CONTINUE READING

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