DHA does not protect ELOVL4 transgenic mice from retinal degeneration

@article{Li2009DHADN,
  title={DHA does not protect ELOVL4 transgenic mice from retinal degeneration},
  author={Feng Li and Lea D. Marchette and Richard S. Brush and Michael H. Elliott and Yun Zheng Le and Kimberly Henry and Ashley G. Anderson and Chao Zhao and Xufang Sun and Kang Zhang and Robert E. Anderson},
  journal={Molecular Vision},
  year={2009},
  volume={15},
  pages={1185 - 1193}
}
PURPOSE Dominant Stargardt macular dystrophy (STGD3) is caused by several different mutations in a gene named ELOVL4, which shares sequence homologies with a family of genes that encode proteins involved in the ELOngation of Very Long chain fatty acids. Studies have suggested that patients with STGD3 have aberrant metabolism of docosahexaenoic acid (DHA, 22:6n3), the major polyunsaturated fatty acid (PUFA) in retinal rod outer segment membranes. We tested the effect of DHA on the progression of… CONTINUE READING

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