DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APP<ce:inf loc=post>swe</ce:inf>/PS1<ce:inf loc=post>dE9</ce:inf> mice

@article{Hooijmans2009DHAAC,
  title={DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APP<ce:inf loc=post>swe</ce:inf>/PS1<ce:inf loc=post>dE9</ce:inf> mice},
  author={Carlijn R Hooijmans and Catharina E. E. M. van der Zee and Pieter J. W. C. Dederen and Katrien M. Brouwer and Amanda J Kiliaan},
  journal={Neurobiology of Disease},
  year={2009},
  volume={33},
  pages={482-498}
}
Cholesterol and docosahexenoic acid (DHA) may affect degenerative processes in Alzheimer's Disease (AD) by influencing Abeta metabolism indirectly via the vasculature. We investigated whether DHA-enriched diets or cholesterol-containing Typical Western Diets (TWD) alter behavior and cognition, cerebral hemodynamics (relative cerebral blood volume (rCBV)) and Abeta deposition in 8- and 15-month-old APP(swe)/PS1(dE9) mice. In addition we investigated whether changes in rCBV precede changes in… CONTINUE READING

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