DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal

@article{Wang2007DGCR8IE,
  title={DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal},
  author={Yangming Wang and Rostislav Medvid and Collin Melton and Rudolf Jaenisch and Robert Blelloch},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={380-385}
}
The molecular controls that govern the differentiation of embryonic stem (ES) cells remain poorly understood. DGCR8 is an RNA-binding protein that assists the RNase III enzyme Drosha in the processing of microRNAs (miRNAs), a subclass of small RNAs. Here we study the role of miRNAs in ES cell differentiation by generating a Dgcr8 knockout model. Analysis of mouse knockout ES cells shows that DGCR8 is essential for biogenesis of miRNAs. On the induction of differentiation, DGCR8-deficient ES… CONTINUE READING
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