DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs.

@article{Macas2015DGCR8AA,
  title={DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs.},
  author={Sara Mac{\'i}as and Ross A. Cordiner and Philippe Gautier and Mireya Plass and Javier F C{\'a}ceres},
  journal={Molecular cell},
  year={2015},
  volume={60 6},
  pages={873-85}
}
The Microprocessor complex (DGCR8/Drosha) is required for microRNA (miRNA) biogenesis but also binds and regulates the stability of several types of cellular RNAs. Of particular interest, DGCR8 controls the stability of mature small nucleolar RNA (snoRNA) transcripts independently of Drosha, suggesting the existence of alternative DGCR8 complex(es) with other nucleases to process a variety of cellular RNAs. Here, we found that DGCR8 copurifies with subunits of the nuclear exosome… CONTINUE READING