DFNB89, a novel autosomal recessive nonsyndromic hearing impairment locus on chromosome 16q21-q23.2

@article{Basit2010DFNB89AN,
  title={DFNB89, a novel autosomal recessive nonsyndromic hearing impairment locus on chromosome 16q21-q23.2},
  author={Sulman Basit and Kwanghyuk Lee and Rabia Habib and Leon L Chen and Umm-e-Kalsoom and Regie Lyn P. Santos-Cortez and Zahid Azeem and Paula Baloni Andrade and Muhammad Ansar and Wasim Ahmad and Suzanne M. Leal},
  journal={Human Genetics},
  year={2010},
  volume={129},
  pages={379-385}
}
DFNB89 is a novel autosomal recessive nonsyndromic hearing impairment (ARNSHI) locus that was mapped to 16q21-q23.2. Linkage to the region was established by carrying out genome-wide linkage scans in two unrelated, consanguineous Pakistani families segregating ARNSHI. The maximum multipoint LOD score is 9.7 for both families and for each family, a significant maximum LOD score of 6.0 and 3.7 were obtained. The 3-unit support interval and the region of homozygosity for the two families extend… Expand
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