DEVELOPMENT OF RECENT THOUGHTS ON INTRACRANIAL PRESSURE AND THE BLOOD-BRAIN BARRIER.
@article{Fox1964DEVELOPMENTOR, title={DEVELOPMENT OF RECENT THOUGHTS ON INTRACRANIAL PRESSURE AND THE BLOOD-BRAIN BARRIER.}, author={J. L. Fox}, journal={Journal of neurosurgery}, year={1964}, volume={21}, pages={ 909-67 } }
W HAT unique situation in the human body may result from capillary blood flow shearing across electrically charged semipermeable proteolipidic membranes of abutting endothelial and glial cells in the absence of adequate pericapillary interstitial space in the brain ? A phenomenon known for decades as the blood-brain barrier may be the precocious answer to this question. Only after these specialized membranes appeared could the neuraxis be protected from variations in the extracellular fluid of…
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References
SHOWING 1-10 OF 561 REFERENCES
The Blood-Brain Barrier: An Expression of the Absence of Interstitial Spaces in Ectodermal Tissue?
- Medicine, Biology
- 1961
This investigation of cyst fluids initiated a review of the subject of the blood-brain barrier, which proved so interesting that it has sidetracked the original problem.
AN EXPLANATION OF THE BLOOD‐BRAIN BARRIER PHENOMENON
- Medicine, Biology
- 1958
The anatomical substratum for the barrier phenomenon has long been a subject of discussion and in a review of contemporary theories Spatz (1933) found valid arguments to reject all of them but one.
The blood—brain barrier and the extracellular space of brain
- BiologyThe Journal of physiology
- 1959
In the present work, the penetration of 1311, sucrose andp-aminohippurate (PAH) into brain and muscle is studied.
ON BASIC ASPECTS OF THE BLOOD‐BRAIN BARRIER
- BiologyActa psychiatrica et neurologica Scandinavica
- 1955
The existence of a blood-brain barrier (BBB) has been discussed for more than 40 years; it has been criticized or even rejected by some investigators, though most have preferred not to adopt a…
Changes in the blood-brain barrier after exposure of the brain.
- BiologyA.M.A. archives of neurology and psychiatry
- 1957
These experiments showed that cerebral vessels undergo an increase in permeability to trypan blue when the brain is exposed to air, and Apfelbach, Bonvallet and Le Beau, and Obrador and Pi-Suner failed to observe such an increasein trypanblue permeability in their experiments on cerebral edema resulting from exposure or from other experimental procedures.
Physiological salt solutions for brain surgery; studies of local pH and pial vessel reactions to buffered and unbuffered isotonic solutions.
- MedicineJournal of neurosurgery
- 1949
The study of irrigation fluids for use on the exposed brain, which forms the subject of the present report, is a part of a series of investigations on the general problem of the reaction of the brain to exposure which is being carried out under the direction of Professor Wilder Penfield.
SILVER DEPOSITION IN THE CENTRAL NERVOUS SYSTEM AND THE HEMATOENCEPHALIC BARRIER STUDIED WITH THE ELECTRON MICROSCOPE
- BiologyThe Journal of biophysical and biochemical cytology
- 1955
Two levels of the hematoencephalic barrier were apparently demonstrated in investigations and silver deposition was found in the perivascular spaces in the choroid plexus, area postrema, and in minute quantities in the cerebrum, cerebellum, and most of the medulla.
THE DEVELOPMENT OF THE BLOOD‐BRAIN BARRIER *
- Biology
- 1957
Evidence which may be interpreted as indicating a decreased function of the bloodbrain barrier in the immature brain has been summarized and discussed elsewhere and, therefore, only observations of direct bearing on the findings, presented below, will be considered.
Blood-brain barrier and ground substance of central nervous system; effect of brain wounds.
- BiologyA.M.A. archives of neurology and psychiatry
- 1955
It has been suggested that there is an additional element in the central nervous system, the ground substance, which is probably of a carbohydrate-protein nature (Hess,51953), and trypan blue, administered intravenously or intraperitoneally, is a valid test substance for the presence or absence of a blood-brain barrier.
Experimental study of the effects of hypothermia on local brain injury
- MedicineNeurology
- 1960
Cerebral edema with its relationship to the permeability of the blood-brain barrier and the behavior of the tissue elements has been studied recently by this group and it was found possible to make a highly reproducible brain lesion, the dynamics of which could be followed chronologically.