DEVELOPMENT OF A PERTUSSIS COMPONENT VACCINE IN JAPAN

@article{Sato1984DEVELOPMENTOA,
  title={DEVELOPMENT OF A PERTUSSIS COMPONENT VACCINE IN JAPAN},
  author={Y. Sato and M. Kimura and H. Fukumi},
  journal={The Lancet},
  year={1984},
  volume={323},
  pages={122-126}
}
  • Y. Sato, M. Kimura, H. Fukumi
  • Published 1984
  • Medicine
  • The Lancet
  • Antibodies against two physicochemically purified haemagglutinins (HAs) of Bordetella pertussis (filamentous HA and leucocytosis-promoting-factor HA) protect laboratory animals from pertussis. A vaccine containing these two HAs was prepared and tested in trials involving about 5000 children. Culture supernatant of Bordetella pertussis, phase I, was treated with ammonium sulphate, and a crude extract of the HAs was extracted from the precipitate by the use of concentrated sodium chloride. This… CONTINUE READING
    An improved whole cell pertussis vaccine with reduced content of endotoxin
    • 35
    Mutants of pertussis toxin suitable for vaccine development.
    • 288

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