DEPROTONATION DYNAMICS OF LOCAL ANESTHETICS IN HYDROPHOBIC MEDIA: DIBUCAINEHCI IN WATER/ALCOHOL OR SURFACTANT MIXTURES

@article{Lin1988DEPROTONATIONDO,
  title={DEPROTONATION DYNAMICS OF LOCAL ANESTHETICS IN HYDROPHOBIC MEDIA: DIBUCAINEHCI IN WATER/ALCOHOL OR SURFACTANT MIXTURES},
  author={C. Lin and L. Williamson and Y. Chyan and A. Marques},
  journal={Photochemistry and Photobiology},
  year={1988},
  volume={48}
}
Abstract— The emitting chromophores, emitting states, state orderings and phosphorescence lifetimes of neutral, hydrogen‐bonded, and protonated dibucaines in water/alcohol mixtures were determined experimentally and were confirmed theoretically using a HAM/3 method. These photophysical properties are used to probe the deprotonation dynamics of dibucaine‐HCl in the water/hydrophobic media. It is found that the protonated dibucaine in an aqueous solution is deprotonated and/or forms hydrogen… Expand
PHOTOPHYSICAL STUDIES OF LOCAL ANESTHETICS, TETRACAINE and PROCAINE: DRUG AGGREGATIONS
TLDR
The monocation and free base local anesthetics in ethanol solutions give identical photophysical properties, suggesting that the monocation drug species in ethanol is H+ dissociative. Expand
The species of 8-methoxy-psoralen in hydrophobic and hydrophilic environments and its solubilization in neutral and charged micelles
Abstract 8-methoxy-psoralen (8MOP), was studied with UV absorption spectroscopy at room temperature and steady state and time-resolved emission spectroscopic techniques at 77 K. UV absorption spectraExpand
Fluorescence studies of a local anesthetic-phospholipid interaction.
TLDR
Steady-state and time-resolved fluorescence data are reported for the local anesthetic dibucaine in the absence and presence of phospholipid vesicles and there is no evidence that the rotational motion of bound dibiaucaine is anisotropic. Expand
SOLUBILIZATION SITES AND ACID‐BASE FORMS OF DIBUCAINE‐HYDROCHLORIDE IN NEUTRAL AND CHARGED MICELLAR SOLUTIONS
  • C. Mertz, C. Lin
  • Chemistry, Medicine
  • Photochemistry and photobiology
  • 1991
TLDR
The distinct properties observed for the drug species of dibucaine and their solubilization sites in micelles are consistent with a balance between hydrophobic forces, surface polarity and the interfacial electrostatic potential present in the micellar solubILization sites. Expand
SPECTROSCOPIC STUDIES OF COUMARIN IN MICELLES
TLDR
It was found that a fifth species of coumarin assigned as the “action species” is solubilized into the interior of micelles, which could lend some insight into the mechanism of transporting coumarins across the membrane. Expand
Solubilization study of local anesthetics into sodium dodecyl sulfate micelle using anesthetic cation selective electrodes.
TLDR
The critical micelle concentration (CMC) of mixed micelle was determined as a function of the concentration of free anesthetic, which decreased with an increasing amount of anesthetics solubilized. Expand
Inhibition of the transthylakoid gradient of electrochemical proton potential by the local anesthetic dibucaine
TLDR
Investigation of the effects of the local anesthetic dibucaine on coupling between electron transport and ATP synthesis-hydrolysis by the coupling-factor complex (CF0CF1 ATPase) and the mechanisms of action of local anesthetics at the thylakoid membrane presented evidence that inhibition of ATP synthesis was produced by a specific uncoupling mechanism which was based on dibuccaine-membrane surface interactions. Expand
Spectrophotometric study of interaction and solubilization of procaine hydrochloride in micellar systems
The interaction of Procaine hydrochloride (PC) with cationic, anionic and non-ionic surfactants; cetyltrimethylammonium bromide (CTAB), sodium dodecyl sulfate (SDS) and triton X-100, wereExpand

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