DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer.

@article{Fu1997DEKAA,
  title={DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer.},
  author={Glenn K. Fu and Gerard C. Grosveld and David M. Markovitz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 5},
  pages={
          1811-5
        }
}
The product of the dek oncogene is the 43-kDa DEK nuclear protein. DEK was first identified in a fusion with the CAN nucleoporin protein in a specific subtype of acute myelogenous leukemia. DEK has also been shown to be an autoantigen in patients with pauciarticular onset juvenile rheumatoid arthritis. Further, the last 65 amino acids of DEK can partially reverse the mutation-prone phenotype of cells from patients with ataxia-telangiectasia. However, in spite of these significant disease… CONTINUE READING
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