DEGAS: De Novo Discovery of Dysregulated Pathways in Human Diseases

@inproceedings{Ulitsky2010DEGASDN,
  title={DEGAS: De Novo Discovery of Dysregulated Pathways in Human Diseases},
  author={Igor Ulitsky and Akshay Krishnamurthy and Richard M. Karp and Ron Shamir},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Molecular studies of the human disease transcriptome typically involve a search for genes whose expression is significantly dysregulated in sick individuals compared to healthy controls. Recent studies have found that only a small number of the genes in human disease-related pathways show consistent dysregulation in sick individuals. However, those studies found that some pathway genes are affected in most sick individuals, but genes can differ among individuals. While a pathway is… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 83 references

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 7 Excerpts
Highly Influenced

A census of human cancer genes

Nature Reviews Cancer • 2004
View 3 Excerpts
Highly Influenced

NCBI GEO: archive for high-throughput functional genomic data

Nucleic Acids Research • 2009
View 3 Excerpts
Highly Influenced

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