DEDD and DEDD2 associate with caspase-8/10 and signal cell death

@article{Alcivar2003DEDDAD,
  title={DEDD and DEDD2 associate with caspase-8/10 and signal cell death},
  author={Allison Alcivar and Shimin Hu and Jun Tang and Xiaolu Yang},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={291-297}
}
An apoptotic signal triggered by cell surface death receptors is disseminated to intracellular compartments through protein–protein interactions mediated by conserved domains such as the death effector domain (DED). A unique family of single DED-containing proteins, including DEDD and DEDD2, is targeted to the nucleolus. However, the role of DEDD/DEDD2 in apoptosis remains less understood. Here we show that DEDD and DEDD2 are highly conserved in diverse species, and that they are potent… CONTINUE READING
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