DECREASED EXPRESSION OF THE MEMORY MARKER CD26 ON BOTH CD4+ AND CD8+ T-LYMPHOCYTES OF HIV-INFECTED SUBJECTS

@article{Vanham1993DECREASEDEO,
  title={DECREASED EXPRESSION OF THE MEMORY MARKER CD26 ON BOTH CD4+ AND CD8+ T-LYMPHOCYTES OF HIV-INFECTED SUBJECTS},
  author={G L E E Vanham and Luc Kestens and Ingrid De Meester and Johan H Vingerhoets and Godelieve Penne and G C Vanhoof and Simon L Scharp{\'e} and Harie Heyligen and Eug{\`e}ne Bosmans and Jan L Ceuppens},
  journal={Journal of acquired immune deficiency syndromes},
  year={1993},
  volume={6 7},
  pages={
          749-57
        }
}
Using a novel anti-CD26 (or anti-dipeptidyl peptidase IV) monoclonal antibody, we showed that the absolute numbers and the proportions of T4 and T8 cells expressing CD26 were significantly lower in HIV-infected persons than in controls. The absolute number of CD26+ T4 cells decreased according to disease progression, whereas the number of CD26+ T8 cells was low throughout all clinical stages. These trends were similar in CD26 dim and bright positive T-cell subsets. In both controls and HIV… CONTINUE READING
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