DEC1 and DEC2 Crosstalk between Circadian Rhythm and Tumor Progression.

  title={DEC1 and DEC2 Crosstalk between Circadian Rhythm and Tumor Progression.},
  author={Fuyuki Sato and U K Bhawal and Tomohiro Yoshimura and Yasuteru Muragaki},
  journal={Journal of Cancer},
  volume={7 2},
Clock genes, major regulators of circadian rhythm, are involved in tumor progression. We have shown that clock genes basic helix-loop-helix (BHLH) transcription factors, differentiated embryonic chondrocyte gene 1 (DEC1/BHLHE40/Sharp2/Stra13) and DEC2 (BHLHE41/Sharp1) play important roles in circadian rhythm, cell proliferation, apoptosis, hypoxia response, various stresses, and epithelial-to-mesenchymal transition (EMT) of tumor cells. Various stresses, such as exposure to transforming growth… CONTINUE READING
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