DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes.

@article{Bozzacco2007DEC205RO,
  title={DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes.},
  author={Leonia Bozzacco and Christine Trumpfheller and Frederick P. Siegal and Saurabh Mehandru and Martin Markowitz and Mary N Carrington and Michel C. Nussenzweig and Angela Granelli Piperno and Ralph Marvin Steinman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 4},
  pages={1289-94}
}
Optimal HIV vaccines should elicit CD8+ T cells specific for HIV proteins presented on MHC class I products, because these T cells contribute to host resistance to viruses. We had previously found that the targeting of antigen to dendritic cells (DCs) in mice efficiently induces CD8+ T cell responses. To extend this finding to humans, we introduced the HIV p24 gag protein into a mAb that targets DEC-205/CD205, an endocytic receptor of DCs. We then assessed cross-presentation, which is the… CONTINUE READING
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