DEAF-1, a novel protein that binds an essential region in a Deformed response element.

@article{Gross1996DEAF1AN,
  title={DEAF-1, a novel protein that binds an essential region in a Deformed response element.},
  author={C T Gross and William J. McGinnis},
  journal={The EMBO journal},
  year={1996},
  volume={15 8},
  pages={1961-70}
}
A 120 bp homeotic response element that is regulated specifically by Deformed in Drosophila embryos contains a single binding site for Deformed protein. However, a 24 bp sub-element containing this site does not constitute a Deformed response element. Specific activation requires a second region in the 120 bp element, which presumably contains one or more binding sites for Deformed cofactors. We have isolated a novel protein from Drosophila nuclear extracts which binds specifically to a site in… CONTINUE READING

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