DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene

@article{Tanaka2018DEADBP,
  title={DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene},
  author={K. Tanaka and Narumi Ikeda and K. Miyashita and H. Nuriya and T. Hara},
  journal={Cancer Science},
  year={2018},
  volume={109},
  pages={2479 - 2489}
}
  • K. Tanaka, Narumi Ikeda, +2 authors T. Hara
  • Published 2018
  • Biology, Medicine
  • Cancer Science
  • DDX1, a member of the DEAD box RNA helicase family, plays a critical role in testicular tumors. However, it remains to be clarified whether DDX1 is involved in other types of malignant tumors such as colorectal cancer. We disrupted the DDX1 gene in a human colorectal cancer cell line LoVo using the CRISPR/Cas9‐mediated gene‐targeting system. DDX1‐KO LoVo cells exhibited a much slower growth rate, produced fewer colonies in soft agar medium, and generated smaller solid tumors in nude mice than… CONTINUE READING
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