DEAD Box Protein DDX1 Regulates Cytoplasmic Localization of KSRP

  title={DEAD Box Protein DDX1 Regulates Cytoplasmic Localization of KSRP},
  author={Chu-Fang Chou and Wei-Jye Lin and Chen-Chung Lin and Christian A. Luber and Roseline Godbout and Matthias Mann and Ching-Yi Chen},
  booktitle={PloS one},
mRNA decay mediated by the AU-rich elements (AREs) is one of the most studied post-transcriptional mechanisms and is modulated by ARE-binding proteins (ARE-BPs). To understand the regulation of K homology splicing regulatory protein (KSRP), a decay-promoting ARE-BP, we purified KSRP protein complexes and identified an RNA helicase, DDX1. We showed that down-regulation of DDX1 expression elevated cytoplasmic levels of KSRP and facilitated ARE-mediated mRNA decay. Association of KSRP with 14-3-3… CONTINUE READING
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