DDT inhibits the functional activation of murine macrophages and decreases resistance to infection by Mycobacterium microti.

@article{MaraAndreaNuez2002DDTIT,
  title={DDT inhibits the functional activation of murine macrophages and decreases resistance to infection by Mycobacterium microti.},
  author={G Mar{\'i}aAndreaNu{\~n}ez and Iris Estrada and Emma S Calder{\'o}n-Aranda},
  journal={Toxicology},
  year={2002},
  volume={174 3},
  pages={201-10}
}
DDT is still widely used in several parts of the world to control malaria, typhoid and dengue vectors, even though its use was banned in many countries based on toxicity data in wild life species. DDT has been shown to have immunotoxic effects in mice and to increase susceptibility to intracellular pathogens such as Mycobacterium leprae. However, little is known about the mechanisms underlying this effect. Activated macrophages play an important defensive role against intracellular pathogens… CONTINUE READING