DDT-induced oxidative damage in human blood mononuclear cells.

  title={DDT-induced oxidative damage in human blood mononuclear cells.},
  author={Iv{\'a}n N P{\'e}rez-Maldonado and Crisp{\'i}n Herrera and Lilia E. Batres and Roberto Gonz{\'a}lez-Amaro and Fernando Mart{\'i}nez D{\'i}az-Barriga and Leticia Y{\'a}{\~n}ez},
  journal={Environmental research},
  volume={98 2},
Recent work indicates that DDT and its metabolites induce apoptosis in different cellular types. However, the mechanism by which DDT generates apoptosis has not been elucidated. In this study, our data demonstrate that the apoptosis induction by DDT and its metabolites in human peripheral blood mononuclear cells (PBMC) is preceded by an increase in the levels of reactive oxygen species (ROS). Cells isolated from healthy individuals were incubated for different intervals of time (0-24 h) and in… CONTINUE READING
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