Corpus ID: 31537488

DDT-induced myoclonus: serotonin and alpha noradrenergic interaction.

  title={DDT-induced myoclonus: serotonin and alpha noradrenergic interaction.},
  author={Eunyong Chung Hwang and Melvin H. Van Woert},
  journal={Research communications in chemical pathology and pharmacology},
  volume={23 2},
p,p'-DDT (600 mg/kg) produces myoclonic activity in mice which can be reduced by L-5-hydroxytryptophan (L-5HTP) (200 mg/kg), H75/12 (25 mg/kg), serotonin uptake blockers and two alpha-receptor blockers, phenoxybenzamine (5 mg/kg) and trazodone (5 mg/kg). Decreasing endogenous brain serotonin by pretreatment with p-chlorophenylalanine (400 mg/kg i.p.) blocked the antimyoclonic action of all of these drugs except L-5HTP. Seven other alpha-receptor blockers (phentolamine, tolazoline, yohimbine… Expand
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The effect of memantine, an NMDA receptor antagonist, on the intensity of myoclonic jerks and the extent of cerebral ischemia-induced neurodegeneration in the cerebellum were evaluated in a rat model of posthypoxic myoclonus, suggesting that glutaminergic NMda receptor activation in the Cerebellum does not play a significant role in the generation of myoc Lonus. Expand
Toxicological profile for DDT, DDE, and DDD
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