DDR1 signaling is essential to sustain Stat5 function during lactogenesis.

  title={DDR1 signaling is essential to sustain Stat5 function during lactogenesis.},
  author={Elena Faraci-Orf and Catherine McFadden and Wolfgang F. Vogel},
  journal={Journal of cellular biochemistry},
  volume={97 1},
Postnatal development of the mammary gland is achieved by an interplay of endocrine and extracellular matrix-derived signals. Despite intense research, a comprehensive understanding of the temporal and spatial coordination of these hormonal and basement membrane stimuli is still lacking. Here, we address the role of the collagen-receptor DDR1 in integrating extracellular matrix-derived signaling with the lactogenic pathway initiated by the prolactin receptor. We found that stimulation of DDR1… CONTINUE READING

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