DDB complexities.

  title={DDB complexities.},
  author={Birgitte \O. Wittschieben and Richard D Wood},
  journal={DNA repair},
  volume={2 9},
A group of recent publications contribute new insights concerning the role of the DNA damage-binding protein complex (DDB) in DNA repair. Mutations in the 48kDa DDB2 subunit are now found in all confirmed cases of xeroderma pigmentosum complementation group E. Several studies have reported a connection between the 127kDa DDB1 subunit and proteins involved in ubiquitin-mediated proteolysis. One such multiprotein complex containing DDB1 and DDB2 is closely related to a complex containing DDB1 and… CONTINUE READING


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