DDB accumulates at DNA damage sites immediately after UV irradiation and directly stimulates nucleotide excision repair.

@article{Wakasugi2002DDBAA,
  title={DDB accumulates at DNA damage sites immediately after UV irradiation and directly stimulates nucleotide excision repair.},
  author={Mitsuo Wakasugi and Aki Kawashima and Hiroshi Morioka and S. Linn and Aziz Sancar and Toshio Mori and Osamu Nikaido and Tsukasa Matsunaga},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 3},
  pages={1637-40}
}
Damaged DNA-binding protein, DDB, is a heterodimer of p127 and p48 with a high specificity for binding to several types of DNA damage. Mutations in the p48 gene that cause the loss of DDB activity were found in a subset of xeroderma pigmentosum complementation group E (XP-E) patients and have linked to the deficiency in global genomic repair of cyclobutane pyrimidine dimers (CPDs) in these cells. Here we show that with a highly defined system of purified repair factors, DDB can greatly… CONTINUE READING

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