DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer.

  title={DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer.},
  author={D. Scott Hessels and Jacqueline M T Klein Gunnewiek and Inge M van Oort and Herbert F. M. Karthaus and Geert J. L. H. van Leenders and Bianca van Balken and Lambertus A Kiemeney and Johannes Alfred Witjes and Jack A Schalken},
  journal={European urology},
  volume={44 1},
  pages={8-15; discussion 15-6}
BACKGROUND DD3(PCA3) is the most prostate cancer-specific gene described to date. To assess the clinical utility of DD3(PCA3) a time-resolved fluorescence-based, quantitative RT-PCR analysis for DD3(PCA3) was developed. METHODS The diagnostic potential of DD3(PCA3) was determined by quantitative measurement of DD3(PCA3) transcripts in non-malignant and malignant prostate specimens. Moreover, DD3(PCA3) transcripts were determined quantitatively in urine sediments obtained after prostatic… CONTINUE READING
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A time - resolved fluorescence - based determination of DD 3 PCA 3 mRNA : a new sensitive tool for prostate cancer diagnosis

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