DD-ligases as a potential target for antibiotics: past, present and future.

  title={DD-ligases as a potential target for antibiotics: past, present and future.},
  author={Isabelle Tytgat and Evelina Colacino and Paul M Tulkens and Jacques H. Poupaert and Martine Pr{\'e}vost and Françoise Van Bambeke},
  journal={Current medicinal chemistry},
  volume={16 20},
DD-ligases catalyze the synthesis of the D-Ala-D-Ala and D-Ala-D-Ser dipeptides or the D Ala-D-Lac depsipeptide in an early step of peptidoglycan synthesis. Their function is essential for bacterial growth and specific to bacteria, making them attractive targets for the development of novel antibiotics. This review examines the biochemical and structural features of these enzymes and presents the main families of inhibitors described so far. Over the last 20 years, 7 structures of DD-ligases… CONTINUE READING


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