DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27

@article{Sigmundsdttir2007DCsMS,
  title={DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27},
  author={Hekla Sigmundsd{\'o}ttir and Junliang Pan and Gudrun F Debes and Carsten Alt and Aida Habtezion and Dulce Soler and Eugene C. Butcher},
  journal={Nature Immunology},
  year={2007},
  volume={8},
  pages={285-293}
}
During adaptive immune responses, dendritic cells activate T cells and endow them with specific homing properties. Mechanisms that 'imprint' specific tropisms, however, are not well defined. We show here that 1,25(OH)2D3, the active form of vitamin D3, signaled T cells to express CC chemokine receptor 10, which enabled them to migrate to the skin-specific chemokine CCL27 secreted by keratinocytes of the epidermis. In contrast, 1,25(OH)2D3 suppressed the gut-homing receptors α4β7 and CCR9… Expand
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