DCS‐1, DCS‐2, and DFV share amino acid substitutions at the extracellular RhD protein vestibule

@article{Flegel2008DCS1DA,
  title={DCS‐1, DCS‐2, and DFV share amino acid substitutions at the extracellular RhD protein vestibule},
  author={Willy Albert Flegel and Inge von Zabern and Andrea Doescher and Franz Friedrich Wagner and Jindři{\vs}ka Vytiskov{\'a} and Martin P{\'i}{\vs}acka},
  journal={Transfusion},
  year={2008},
  volume={48}
}
BACKGROUND: RhD and RhCE are structurally related to ammonium transporter proteins, yet their physiologic function remains unclear. Recent three‐dimensional homology modeling with Escherichia coli AmtB as a template defined a putative transmembraneous channel. Three RhD variants with amino acid substitutions located at the extracellular channel aperture are described. 

Full‐length nucleotide sequence of ERMAP alleles encoding Scianna (SC) antigens

Scianna (SC) blood group system comprises two antithetical antigens, Sc1 and Sc2, and five additional antigens. The antigens reside on a glycoprotein encoded by the erythroblast membrane–associated

D variants at the RhD vestibule in the weak D type 4 and Eurasian D clusters

TLDR
One branch of the RHD phylogenetic tree is represented by the weak D type 4 cluster of alleles with F223V as the primordial amino acid substitution with a large number of further substitutions causing D variants located at the extracellular RhD protein vestibule.

Insights into anti‐D formation in carriers of RhD variants through studies of 3D intraprotein interactions

Many RhD variants associated with anti‐D formation (partial D) in carriers exposed to the conventional D antigen carry mutations affecting extracellular loop residues. Surprisingly, some carry

The DAU cluster: a comparative analysis of 18 RHD alleles, some forming partial D antigens

TLDR
The DaU cluster of RHD alleles is characterized by the single‐nucleotide change producing the p.Thr379Met amino acid substitution and has been postulated to be the primordial allele, from which all other alleles of the DAU cluster have eventually evolved.

Molecular genetics and clinical applications for RH.

  • W. Flegel
  • Biology, Medicine
    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
  • 2011

Alloimmunization risk associated with amino acid 223 substitution in the RhD protein: analysis in the light of molecular modeling

TLDR
A three‐dimensional (3D) structural model is built to investigate the consequences of substitutions of Amino Acid 223 involved in a large number of D variants.

Genetic variation of the whole ICAM4 gene in Caucasians and African Americans

Landsteiner‐Wiener (LW) is the human blood group system Number 16, which comprises two antithetical antigens, LWa and LWb and the high‐prevalence antigen LWab. LW is encoded by the intracellular

D category IV: a group of clinically relevant and phylogenetically diverse partial D

The D typing strategies in several European countries protect carriers of D category VI (DVI) from anti‐D immunization but not carriers of other partial D. Besides DVI, one of the clinically most

Molecular analysis of inactive and active RHD alleles in native Congolese cohorts

TLDR
This study identified inactive and active RHD alleles at the molecular level in Congolese cohorts and confirmed the importance of knowing the carrier and removal status of these alleles in the context of RHD infection.

RhCE protein variants in Southwestern Germany detected by serologic routine testing

TLDR
The molecular background of variant RhCE antigens identified by standard serologic routine testing in German blood donors and patients was determined.

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