DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma

@inproceedings{Weygant2015DCLK1IA,
  title={DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma},
  author={Nathaniel Weygant and Dongfeng Qu and Randal J May and Ryan M. Tierney and William L Berry and Lichao Zhao and Shweta Agarwal and Parthasarathy Chandrakesan and Harisha R. Chinthalapally and Nicholas T. Murphy and James D. Li and Sripathi M. Sureban and Michael J. Schlosser and James J. Tomasek and Courtney W. Houchen},
  booktitle={Oncotarget},
  year={2015}
}
Renal clear cell carcinoma (RCC) is the most common type of kidney cancer and the 8th most common cancer overall in the US. RCC survival rates drop precipitously with regional and distant spread and recent studies have demonstrated that RCC presents an epithelial-mesenchymal transition (EMT) phenotype linked to increased recurrence and decreased survival. EMT is a key characteristic of tumor stem cells (TSCs) along with chemo-resistance and radio-resistance, which are also phenotypic of RCC… CONTINUE READING