DCG‐IV Selectively Attenuates Rapidly Triggered NMDA‐induced Neurotoxicity in Cortical Neurons

@article{Buisson1996DCGIVSA,
  title={DCG‐IV Selectively Attenuates Rapidly Triggered NMDA‐induced Neurotoxicity in Cortical Neurons},
  author={Alain Buisson and S. P. Yu and Dennis W. Choi},
  journal={European Journal of Neuroscience},
  year={1996},
  volume={8}
}
Molecular cloning has revealed the existence of at least eight subtypes of metabotropic glutamate receptors (mGluRs). We examined the effect of (2S, 1′R, 2′R, 3′R)‐2‐(2, 3‐dicarboxycyclopropyl)glycine (DCG‐IV), a selective agonist of the mGluR 2/3 subtype, on excitotoxicity in mouse cortical cell cultures. Addition of DCG‐IV to the exposure medium partially attenuated the rapidly triggered excitotoxic death induced by a 5 min exposure to 200 μM NMDA. This neuroprotective effect was reversed by… Expand
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