DCDC2 is associated with reading disability and modulates neuronal development in the brain.

@article{Meng2005DCDC2IA,
  title={DCDC2 is associated with reading disability and modulates neuronal development in the brain.},
  author={Haiying Meng and Shelley D. Smith and Karl Hager and Matthew D. Held and Jonathan Liu and Richard Keith Olson and Bruce F. Pennington and John Clarence Defries and Joel Gelernter and Thomas Francis O'Reilly-Pol and Stefan Somlo and Pawel Skudlarski and Sally E. Shaywitz and Bennett A. Shaywitz and Karen E. Marchione and Yu Wang and Murugan Paramasivam and Joseph J. Loturco and Grier P. Page and Jeffrey R. Gruen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 47},
  pages={
          17053-8
        }
}
DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide polymorphism markers, we identified a large polymorphic deletion that encodes tandem repeats of putative brain-related transcription factor binding sites in intron 2 of DCDC2. Alleles of this compound repeat are in significant disequilibrium with multiple reading traits. RT-PCR data show that DCDC2 localizes to the regions of the brain where fluent… CONTINUE READING

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