DCC regulates cell adhesion in human colon cancer derived HT-29 cells and associates with ezrin.

@article{Martn2006DCCRC,
  title={DCC regulates cell adhesion in human colon cancer derived HT-29 cells and associates with ezrin.},
  author={Merc{\`e} Mart{\'i}n and Patricia Simon-Assmann and Mich{\`e}le Kedinger and Marianne Martin and Paul H. Mangeat and Francisco X Real and Myriam Fabre},
  journal={European journal of cell biology},
  year={2006},
  volume={85 8},
  pages={769-83}
}
The deleted in colorectal cancer (DCC) gene encodes a 170- to 190-kDa protein of the Immunoglobulin superfamily. Firstly identified as a tumor suppressor gene in human colorectal carcinomas, the main function for DCC has been described in the nervous system as part of a receptor complex for netrin-1. Moreover, roles in mucosecretory cell differentiation and as inducer of apoptosis have also been reported. DCC knockout mice supported a crucial role for this gene in axonal migration, yet… CONTINUE READING

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