DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.

@article{Sureban2011DCAMKL1RE,
  title={DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.},
  author={Sripathi M. Sureban and Randal May and Stan A. Lightfoot and Aimee B Hoskins and Megan Lerner and Daniel Brackett and Russell Postier and Rama Ramanujam and Altaf Mohammed and Chinthalapally V Rao and James H. Wyche and Shrikant Anant and Courtney W. Houchen},
  journal={Cancer research},
  year={2011},
  volume={71 6},
  pages={
          2328-38
        }
}
Pancreatic cancer is an exceptionally aggressive disease in great need of more effective therapeutic options. Epithelial-mesenchymal transition (EMT) plays a key role in cancer invasion and metastasis, and there is a gain of stem cell properties during EMT. Here we report increased expression of the putative pancreatic stem cell marker DCAMKL-1 in an established KRAS transgenic mouse model of pancreatic cancer and in human pancreatic adenocarcinoma. Colocalization of DCAMKL-1 with vimentin, a… CONTINUE READING

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