DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection.

  title={DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection.},
  author={Douglas S Kwon and Glenn B Gregorio and Natacha Bitton and Wayne A. Hendrickson and Dan R. Littman},
  volume={16 1},
Fusion of the human immunodeficiency virus (HIV) to the plasma membrane of target cells is mediated by interaction of its envelope glycoprotein, gp120, with CD4 and appropriate chemokine receptors. gp120 additionally binds to DC-SIGN, a C-type lectin expressed on immature dendritic cells. This interaction does not result in viral fusion, but instead contributes to enhanced infection in trans of target cells that express CD4 and chemokine receptors. Here we show that DC-SIGN mediates rapid… CONTINUE READING
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Endocytic entry of HIV

Y. Feng, C. C. Broder, P. E. Kennedy, E. A. Berger
Curr . activity was measured 48 hr postinfection . Biol . • 2000

Endocytosis and molecular sorting.

Annual review of cell and developmental biology • 1996
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