DC-SIGN: escape mechanism for pathogens

@article{Kooyk2003DCSIGNEM,
  title={DC-SIGN: escape mechanism for pathogens},
  author={Yvette van Kooyk and Teunis B. H. Geijtenbeek},
  journal={Nature Reviews Immunology},
  year={2003},
  volume={3},
  pages={697-709}
}
Dendritic cells (DCs) are crucial in the defence against pathogens. Invading pathogens are recognized by Toll-like receptors (TLRs) and receptors such as C-type lectins expressed on the surface of DCs. However, it is becoming evident that some pathogens, including viruses, such as HIV-1, and non-viral pathogens, such as Mycobacterium tuberculosis, subvert DC functions to escape immune surveillance by targeting the C-type lectin DC-SIGN (DC-specific intercellular adhesion molecule-grabbing… 
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926 Citations

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References

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