DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells

@article{Geijtenbeek2000DCSIGNAD,
  title={DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells},
  author={T. Geijtenbeek and D. Kwon and R. Torensma and S. J. Vliet and G. Duijnhoven and J. Middel and I. Cornelissen and H. Nottet and V. Kewalramani and D. Littman and C. Figdor and Y. Kooyk},
  journal={Cell},
  year={2000},
  volume={100},
  pages={587-597}
}
Dendritic cells (DC) capture microorganisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present these in antigenic form to resting T cells and thus initiate adaptive immune responses. Here, we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC but instead… Expand
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