DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells

@article{Geijtenbeek2000DCSIGNAD,
  title={DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells},
  author={Teunis B. H. Geijtenbeek and Douglas S. Kwon and Ruurd Torensma and Sandra J. van Vliet and Gerard C.F van Duijnhoven and Jeena Middel and Ine M. H. A. Cornelissen and Hans S. L. M. Nottet and Vineet N. KewalRamani and Dan R. Littman and Carl G. Figdor and Yvette van Kooyk},
  journal={Cell},
  year={2000},
  volume={100},
  pages={587-597}
}

Figures from this paper

DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review.

A DC-specific C-type lectin that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120 is described that promotes efficient infection in trans of cells that express CD4 and chemokine receptors.

DC-SIGN promotes exogenous MHC-I-restricted HIV-1 antigen presentation.

It is shown that DC-SIGN expression in B-cell lines dramatically enhances viral internalization and the lectin does not significantly protect captured virions against degradation and promotes MHC-I exogenous presentation of HIV-1 antigens.

Dendritic Cell-Mediated trans-Enhancement of Human Immunodeficiency Virus Type 1 Infectivity Is Independent of DC-SIGN

Dendritic cells enhance human immunodeficiency virus type 1 (HIV-1) infection of CD4+ T lymphocytes in trans using a short hairpin RNA approach, demonstrating that DC-SIGN is not required for efficient trans-enhancement by DCs.

DC-SIGN on B Lymphocytes Is Required For Transmission of HIV-1 to T Lymphocytes

It is shown that a subset of B cells in the blood and tonsils of normal donors expressed DC-SIGN, and that this increased after stimulation in vitro with interleukin 4 and CD40 ligand, with enhanced expression of activation and co-stimulatory molecules CD23, CD58, CD80, and CD86, andCD22.

NOTES Dendritic Cell-Mediated trans -Enhancement of Human Immunodeficiency Virus Type 1 Infectivity Is Independent of DC-SIGN (cid:1)

Using a short hairpin RNA approach, it is demonstrated that DC-SIGN is not required for DC-mediated trans-enhancement of HIV infectivity and HIV-1 particles were internalized and were protected from protease treatment following binding to DCs.

Presentation to T Cells Receptor DC-SIGN Internalizes Antigen for The Dendritic Cell-Specific Adhesion

It is demonstrated that on DCs DC-SIGN is rapidly internalized upon binding of soluble ligand, and detailed analysis using ratio fluorescence imaging and electron microscopy showed thatDC-SIGN-ligand complexes are targeted to late endosomes/lysosomes.

DC-SIGN Increases the Affinity of HIV-1 Envelope Glycoprotein Interaction with CD4

DC-SIGN binding to the HIV envelope protein effectively increases exposure of the CD4 binding site, which in turn contributes to enhancement of infection.

DC-SIGN: a novel HIV receptor on DCs that mediates HIV-1 transmission.

A better understanding of the action of this novel HIV receptor in initial viral infection and subsequent transmission will provide a basis for the design of drugs that inhibit or alter interactions of DC-SIGN with gp120, interfering with HIV-1 dissemination and that may have a therapeutic value in both immunological diseases and/or HIV- 1 infections.
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