DBRF-MEGN method: an algorithm for deducing minimum equivalent gene networks from large-scale gene expression profiles of gene deletion mutants

@article{Kyoda2004DBRFMEGNMA,
  title={DBRF-MEGN method: an algorithm for deducing minimum equivalent gene networks from large-scale gene expression profiles of gene deletion mutants},
  author={K. Kyoda and K. Baba and S. Onami and H. Kitano},
  journal={Bioinformatics},
  year={2004},
  volume={20 16},
  pages={
          2662-75
        }
}
MOTIVATION Large-scale gene expression profiles measured in gene deletion mutants are invaluable sources for identifying gene regulatory networks. Signed directed graph (SDG) is the most common representation of gene networks in genetics and cell biology. However, no practical procedure that deduces SDGs consistent with such profiles has been developed. RESULTS We developed the DBRF-MEGN (difference-based regulation finding-minimum equivalent gene network) method in which an algorithm deduces… Expand
A proof of the DBRF-MEGN method, an algorithm for deducing minimum equivalent gene networks
Reverse engineering gene regulatory networks
Prediction and verification of indirect interactions in densely interconnected regulatory networks
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